AKSELERASI PENCAPAIAN PUBERTAS PADA MENCIT SETELAH PENDEDAHAN XENOESTROGEN BISPHENOL A (BPA) SELAMA DUA GENERASI BERTURUT-TURUT

Adriana Y.D. Lbn Gaol, Albinus Silalahi

Abstract


This study was aimed to understand the impact of bisphenol A (BPA) on the reproductive function of female Swiss Webster mice. F0 female (3 month of age) was exposed intragastrically to 0, 0.5, 50 or 500 BPA in corn oil/kg bw/day from premating (5 weeks), mating (2 weeks), gestation (3 weeks) to lactation period (3 weeks). Female offspring originated from F0 mothers were then randomly selected and used as F1 to be exposed with the same compound and procedure. Females were then observed for body weight, cycle regularity, copulation capability (F0, F1, F2), vaginal opening (VO), first estrous (FE), and anogenital distance (AGD) (F1 and F2). The data showed that chronic and multiroutes exposure to high dose of BPA for two generations can accelerate puberty that marked by the premature vaginal opening and first estrous. Acceleration of puberty was accompanied by the increased in body weight, prolongation of cycle, and the tendency of suppression of copulation capability without any changes in AGD at PND 0. These results indicate that BPA could disrupt reproductive function of female mice when exposed chronically, multiroutes and multigenerational. This data can be used as an invaluable reference to access the impact of BPA, and other xenoestrogen, on the human reproductive health.

 

Keywords: Acceleration of puberty, bisphenol A (BPA), reproductive function, female mice, xenoestrogen


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